Metabolic and basal research

At the LUMC we combine pre-clinical research in cells and animal models with clinical trials involving patients who come to the LUMC for the diagnosis and treatment of complex metabolic diseases. This lets us harness the strengths of the pre-clinical and clinical research community within the Prevention & Lifestyle theme to discover and develop new treatments.

We aim to increase the knowledge on the underlying mechanisms or modes of action of prevention and lifestyle interventions for the general public as well as people with chronic and widespread diseases. For this, we closely collaborate with some of the other themes such as Cancer, Cardio-Vascular, Immunity, Medical Genomics.

The theme is linked to the majority of core facilities at the LUMC and benefits from its excellent network of state-of-the-art resource centers. This includes, but it is not limited to, the Animal Welfare Body, the Biobank, the Center for Proteomics and Metabolomics, the Flow Cytometry core facility and the Microscopy facility. Through the epidemiological work that is carried out within the theme, there furthermore is a strong link to large international databases and national studies, such as the large population-based cohort of the NEO study (Nederlandse Epidemiologie van Obesitas) or the LOAS study (Leiden Outcomes OsteoArthritis Study) both with over 6000 participants that are performed at the LUMC. Our theme is also affiliated with the data infrastructure of the ELAN network which enables collaborations with the primary care physicians in the region.

Email: Info.prevention@lumc.nl