NWO Talent Scheme (Veni, Vidi, Vici)
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NWO, the Dutch Research Council, promotes and finances scientific research at universities and institutes in the Netherlands. Below you will find an overview of the most recent Veni, Vidi, Vici laureates within the LUMC. Former LUMC laureates are listed in the annexes.
About the NWO Talent Scheme
Since 2000, the NWO Talent Scheme aims to promote innovation in Dutch academic research and enhance the career perspectives of young researchers. With this type of personal grant, the top researchers (10-20% of their peer group) have the opportunity to develop their own, innovative line of research. All research performed with those grants fits within LUMC’s research profiles.
…NWO, the Dutch Research Council, promotes and finances scientific research at universities and institutes in the Netherlands. Below you will find an overview of the most recent Veni, Vidi, Vici laureates within the LUMC. Former LUMC laureates are listed in the annexes.
About the NWO Talent Scheme
Since 2000, the NWO Talent Scheme aims to promote innovation in Dutch academic research and enhance the career perspectives of young researchers. With this type of personal grant, the top researchers (10-20% of their peer group) have the opportunity to develop their own, innovative line of research. All research performed with those grants fits within LUMC’s research profiles.
The NWO Talent Scheme has three funding instruments, tailored to various phases in the researcher’s scientific career:
- Veni, for researchers who have recently gained their PhD
- Vidi, for experienced researchers
- Vici, for senior researchers who have demonstrated the ability to develop their own line of research
(Source: NWO Website)
About NWO Veni
About NWO Veni
Veni provides excellent researchers who have recently gained their
NWO Veni
Every minute counts: a mobile brain scan to recognize stroke in the ambulance and trauma helicopter – Matthias van Oosterom – 2023
Dr.ir. M.N. van Oosterom
Department of Radiology
• NWO Veni 2023 – Applied and Engineering Sciences (AES)
• NWO contribution: EUR 320,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Acute brain injuries, such as stroke and brain trauma, are the most common cause of disabilities and a major cause of death. Due to the vulnerability of our brain, enormous amounts of healthy life is lost due to delays in diagnosis and treatment selection. Therefore, this research project investigates if a mobile magnetic detection technology will enable us to quickly determine brain injury outside of the hospital, enabling faster and more efficient treatment.
Vicious viruses and decisive sugars: how antibody-glycosylation protects the nasal mucosa – Willianne Hoepel – 2023
Dr. W. Hoepel
Department of Parasitology
• NWO Veni 2023 – ZonMw
• NWO contribution: EUR 320,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Antibodies are important guards in the respiratory mucosa, protecting against common cold viruses. Antibodies contain sugar structures and changes in these sugar structures affects the antibody-function. This proposal investigates sugar structures of antibodies at mucosal sites. Furthermore, it studies the impact on how changes in sugar structures enhances susceptibility for respiratory infections.
Spotlight on schistosomes: altering the immune-worm interaction to boost immunity – Emma Houlder – 2023
Dr. E.L. Houlder
Department of Parasitology
• NWO Veni 2023 – ZonMw
• NWO contribution: EUR 320,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
200 million people have schistosomiasis, a tropical disease caused parasitic worm infection. Worms can survive for years, and individuals are repeatedly infected. Here, I will investigate how the schistosome worm inhibits dendritic cells (DCs), a key immune cell that could otherwise guide protective immunity. Next I will develop a new therapeutic strategy to spotlight the worm to DCs, changing the DC-schistosome interaction. This strategy aims to enable DCs to boost immune responses to schistosomes, providing protection from infection.
Personalized treatments for chronic kidney disease: which medications work for whom? – Edouard Fu – 2023
Dr. E.L. Fu
Department of Clinical Epidemiology
• NWO Veni 2023 – ZonMw
• NWO contribution: EUR 320,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
This research focuses on optimizing the treatment for patients with chronic kidney disease. To reduce their risks for kidney failure requiring dialysis and cardiovascular diseases, medications are required, but their effectiveness varies per individual. To prevent unnecessary exposure and side effects, I will investigate which individuals benefit from these medications and which do not. For this purpose, I will use new and advanced machine learning techniques and large amounts of health data. Clinical providers will be able to use the results of this research in clinical practice to personalize treatments for each unique person with CKD
Getting preterm infants ready for their first breaths by oxygen administration through the placenta - Janneke Dekker – 2023
Dr. J. Dekker
Department of Paediatrics
• NWO Veni 2023 – ZonMw
• NWO contribution: EUR 320,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Prematurely born infants need breathing support to survive after birth. The success of this support is largely dependent on the infant’s breathing effort. Preterm infants’ breaths are often irregular, but can be stimulated by improving the oxygen level of the body through oxygen administration. However, during irregular breathing the vocal cords close, preventing oxygen to reach the lung. Then, breathing is not stimulated and the risk for ventilation and resuscitation increases. This research investigates whether oxygen administration to the mother, via the placenta, will improve the oxygen level of preterm infants before birth and stimulate breathing directly at birth.
Attack on the matrix: unhealthy connective tissue as a target in Crohn's disease – Marieke Barnhoorn – 2023
Dr. M.C. Barnhoorn
Department of Gastroenterology
• NWO Veni 2023 – ZonMw
• NWO contribution: EUR 320,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Crohn's disease, characterized by chronic intestinal inflammation, is currently treated by inhibiting the immune cells in the intestine. However, this treatment does not or hardly help against complications, such as a narrowing of the intestine. I suspect that these complications are caused by a change in the matrix, the connective tissue between all intestinal cells. This is produced by connective tissue cells, which are very numerous in the intestine. This research explains us how this connective tissue is changed in Crohn's disease, and whether we can change the connective tissue cells in such a way that they produce 'healthy' matrix again.
Time is of the essence: multi-dimensional MRI for neurovascular imaging – Lena Vaclavu – 2022
Dr. Dr. L. Vaclavu
Department of Radiology
• NWO Veni 2022 – Applied and Engineering Sciences (AES)
• NWO contribution: EUR 280,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Every organ, and especially our brain, depends on a constant blood
Making oneself at home: How Salmonella hijacks the ubiquitin system to remodel its host cell endocytic architecture and dynamics – Virginie Stévenin - 2022
Dr. Dr. V.M.V. Stévenin
Department of Cell and Chemical Biology
• NWO Veni 2022 – Science
• NWO contribution: EUR 280,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Intracellular bacteria, like Salmonella, are bacteria that enter,
Engineering of efficient and precise Cas12c base editor for genome editing – Prarthana Mohanraju - 2022
Dr. P. Mohanraju
Department of Department of Anatomy and Embryology
• NWO Veni 2022 – Science
• NWO contribution: EUR 280,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Gene editing has unprecedented potential in the development of
A Multi-Modality Imaging Approach – Ilona Dekkers - 2022
Dr. I.A. Dekkers
Department of Radiology
• NWO Veni 2022 – ZonMw
• NWO contribution: EUR 280,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
This proposal aims to investigate the link between chronic kidney
Cancer-associated fibroblasts in oncolytic virus therapy: innocent bystanders or key players? – Vera Kemp - 2021
Dr. Vera Kemp
Department of Cell and Chemical Biology
- NWO VENI 2021 - ZonMw
- NWO contribution: EUR 280.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Oncolytic virus therapy represents a promising anti-cancer approach, specifically targeting cancer cells while leaving normal cells unharmed. Importantly, tumours are shaped by up to 90% of tumour-associated stroma, mainly consisting of cancer-associated fibroblasts. This project uniquely assesses how cancer-associated fibroblasts affect the efficacy of oncolytic virus therapy.
Dementia: yes or no? – Julie Rutten - 2021
Dr. J.W. Rutten
Department of Clinical Genetics
- NWO VENI 2021 - ZonMw
- NWO contribution: EUR 280.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Approximately 25 million individuals worldwide (1:300) have a specific genetic predisposition for stroke and dementia. However, only a minority of these individuals become demented. This study will analyse why some individuals get dementia at a young age, whereas others with the same genetic predisposition remain healthy up to an older age.
Rules of engagement: How do CD4 T-cells decide to help CD8 T-cells or B-cells? – Fiamma Salerno - 2021
Dr. F. Salerno
Department of Immunology
- NWO VENI 2021 - ZonMw
- NWO contribution: EUR 280.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
The immune system protects us against infections and cancer. We can boost the function of our immune cells by administering vaccines. I aim to identify key molecular cues in CD4 T-cells that may help optimize vaccination strategies by simultaneously improving the formation of cytotoxic CD8 T-cells and antibody-producing B-cells.
Tackling cardiometabolic diseases with intestinal hormones – Mariette Boon - 2020
Dr. M.R. Boon
Department of Internal Medicine / Endocrinology
- NWO VENI 2020 - ZonMw
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Obesity is one of the largest health threats to modern society since it contributes to the development of cardiovascular diseases. Recently, combining two intestinal hormones in one pill proved to induce spectacular weight loss. I will study the consequences for cardiometabolic diseases and unravel the underlying mechanisms.
Repairing a broken clock in critically ill patients in the intensive care unit– Laura Kervezee - 2020
Dr. L. Kervezee
Department of Cell and Chemical Biology
- NWO VENI 2020 - ZonMw
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Critically ill patients in the intensive care unit receive feeding 24-h/day and are exposed to inadequate light-dark cycles. This disrupts their circadian clock and gets in the way of a speedy recovery. The researcher will try to strengthen the circadian clock by optimizing the timing of feeding and light exposure.
Age-related clonal hematopoiesis: the good and the bad of clonally expanding immune subsets – Erik van den Akker - 2019
Dr. Ir. E.B. van den Akker
Department of Biomedical Data Sciences / Molecular Epidemiology
- NWO VENI 2019 - ZonMw
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Virtually all exceptionally old individuals have an early form of blood cancer, yet, in contrast to middle-aged individuals, they do not seem to suffer from any adverse effects. What is their secret? This study investigates the protective mechanisms that make the extremely old capable to withstand the test of time.
Treatment of older patients with advanced melanoma - Towards personalized medicine – Nienke de Glas - 2019
Dr. N.A. de Glas
Department of Medical Oncology
- NWO VENI 2019 - ZonMw
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Older patients with cancer are rarely included in immunotherapy trials, leaving oncologists with limited knowledge to make evidence-based treatment decisions. In this project, clinical, geriatric and immunological data will be generated to develop a prognostic model for the clinical benefit of immunotherapy in older patients with melanoma.
Through the eyes of AI: safe and optimal integration of Artificial Intelligence in Radiology – Irene Hernández Girón - 2019
Dr. I. Hernández Girón
Department of Radiology
- NWO VENI 2019 - TTW
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Artificial intelligence will shift the Radiology paradigm, supporting and even replacing radiologists in their diagnostic tasks. There is a risk that these technologies are applied without proper knowledge by users. This research will create a framework to validate and safely integrate artificial intelligence into the clinical workflow.
Deciphering and targeting pathogenic IgG4-responses – Maartje Huijbers - 2019
Dr. M.G.M. Huijbers
Department of Neurology
- NWO VENI 2019 - ZonMw
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
IgG4 is a peculiar antibody. It doesn’t activate inflammatory responses and, in contrast to other antibodies, binds two different antigens. This project will investigate whether the unique properties of IgG4 contribute to the development of IgG4-mediated autoimmune diseases and whether IgG4 immune cells can be therapeutically targeted specifically.
Challenging the elderly brain – Sophie Schmid - 2019
Dr. Ir. S. Schmid
Department of Radiology
- NWO VENI 2019 - TTW
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Vascular components contribute significantly to neurodegeneration in the elderly and constitute one of the first changes, long before clinical symptoms become overt. The researcher aims to develop MRI tools suitable for use in a clinical setting to assess the status of the vasculature in the brain in a non-invasive way.
Besieging the biofilm fortress – Bart Pijls - 2019
Dr. B. Pijls
Department of Orthopaedics
- NWO VENI 2019 - ZonMw
- NWO contribution: EUR 250.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
The main problem with infected implants is that microorganisms are organized in a biofilm, a fortress, protecting them against our immune system and antibiotics. I will use non-invasive induction heating to kill the micro-organisms and damage the biofilm fortress walls in order to cure the infection.
About NWO Vidi
Vidi is aimed at excellent researchers who have already conducted several years of research following their PhD (within 8 years, by submission deadline). They have demonstrated their ability to generate innovative ideas and to successfully and independently develop them. They may develop their own innovative line of research and may appoint scientific staff for the Vidi project.
Since the 2023 round the maximum grant amount is 850,000 euros.
NWO Vidi
Rhythmic hormones for healthy bones – Liesbeth Winter - 2023
Dr. E.M. Winter
Department of Internal Medicine / Endocrinology
• NWO Vidi 2023 – ZonMw
• NWO contribution: EUR 850,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Glucocorticoid-medication is crucial to treat inflammatory diseases, but it is detrimental to many fundamental processes including bone turnover: it leads to osteoporosis with fractures, and thereby loss of quality of life and independency. There is no effective preventive strategy so far. My previous research demonstrated that rhythmicity of glucocorticoids is essential to keep bones healthy. The proposed research will reinstate rhythm in glucocorticoid-signalling during glucocorticoid treatment to secure healthy bones, without compromising its effective treatment of inflammatory diseases. Results will have great impact for all patients dependent on this medication who now suffer from fractures and increased mortality.
VACCINAGE: understanding reduced vaccine responses in older adults – Simon Jochems - 2022
Dr. S.P. Jochems
Department of Parasitology
• NWO Vidi 2022 – ZonMw
• NWO contribution: EUR 800,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
As we age, our susceptibility to infections increases. At the same
COMPOSE: combined imaging for ocular oncology – Jan-Wilem Beenakker - 2021
Dr. J.W.M. Beenakker,
Departments of Ophthalmology & Radiology and Radiotherapy
• NWO Vidi 2021 – AES
• NWO contribution: EUR 800,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
In this research new technologies will be developed to combine
The enigmatic triangle of cluster headache, sleep and the biological clock – Rolf Fronczek - 2021
Dr. R. Fronczek
Department of Neurology
• NWO Vidi 2021 – ZonMw
• NWO contribution: EUR 800,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
People with cluster headache suffer from such excruciating pain
Exploiting gamma-delta (gd) T cells as innovative agents of cancer immunotherapy – Noel de Miranda - 2021
Dr. N.F. de Miranda
Department of Pathology
• NWO Vidi 2021 – ZonMw
• NWO contribution: EUR 800,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Cancer immunotherapy makes use of cells or molecules from our
Protein Dress Up gone wrong – Monique Mulder - 2021
Dr. M.P.C. Mulder
Department of Cell and Chemical biology
• NWO Vidi 2021 – Science
• NWO contribution: EUR 800,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Posttranslational modification of proteins, such as for instance the
A gut feeling about rheumatoid arthritis – Diane van der Woude - 2021
Dr. D. van der Woude
Department of Rheumatology
• NWO Vidi 2021 – ZonMw
• NWO contribution: EUR 800,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Rheumatoid arthritis is caused by a fault in the immune system, that
Finding a recipe to fabricate cell types on command – Anna Alemany - 2020
Dr. A. Alemany
Department of Anatomy and Embryology
- NWO Vidi 2020 - Science
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
All cells in our body share the same genetic information but have different functions and morphologies. The understanding of how the different identities are originated will make us better at generating desired cells from patient-derived stem cells. Here, researchers will investigate the mathematical rules of cell identity establishment.
Malaria parasites taking the tollway – Meta Roestenberg - 2020
Prof. Dr. M. Roestenberg
Department of Parasitology
- NWO Vidi 2020 - ZonMw
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
An effective malaria vaccine is urgently needed. Malaria parasites that are genetically altered cannot cause disease but can be used to train the immune system. To make genetically altered parasites into a very potent vaccine, researchers aim to improve better recognition of the parasite-vaccine by the immune system.
Digging beyond the surface – understanding chronicity in rheumatoid arthritis – Ulrich Scherer - 2020
Dr. H.U. Scherer
Department of Rheumatology
- NWO Vidi 2020 - ZonMw
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Rheumatoid arthritis is a chronic autoimmune disease that will flare when treatment is stopped. Researchers discovered that specific immune cells remain chronically active in patients despite treatment. Here, researchers will use single-cell technology to unravel this immunological disease activity and search for ways to silence it, thereby halting chronicity.
Developing cutting-edge treatments to combat early hereditary blindness – Camiel Boon- 2019
Prof. Dr. C.J.F. Boon
Department of Ophthalmology
- NWO Vidi 2019 - ZonMw
- NWO contribution: EUR 800.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
X-linked juvenile retinoschisis (XLRS) is a relatively common hereditary eye disease, for which there is no treatment. XLRS causes severe vision loss or even blindness in childhood. I will develop a cure for XLRS in experimental models that mimic the disease, based on patient-specific stem cells and an animal model.
Unraveling the role of dystrophin in the brain – Maaike van Putten - 2019
Dr. M. van Putten
Department of Human Genetics
- NWO Vidi 2019 - ZonMw
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Duchenne muscular dystrophy patients suffer from behavioural and learning problems due to a lack of dystrophin in the brain. The researcher will study, in cultured human brain cells, how lack of dystrophin results in abnormalities and to what extent deficits can be remedied by a therapy aimed to restore dystrophin synthesis
Finding a needle in the cellular haystack – Thom Sharp - 2019
Dr. T. Sharp
Department of Cell and Chemical Biology
- NWO Vidi 2019 - Science
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Recent advances in microscopy now allow us to see individual proteins within whole cells. However, cells are so densely packed with molecules that finding the desired protein is like looking for a needle in a haystack. This proposal aims to combine different microscopy techniques to solve this problem, and in doing so, answer long-standing questions in immunology, such as “how does our immune system first interact with germs?”
Inflammation without infection – Annemarthe van der Veen - 2019
Dr. A.G. van der Veen
Department of Immunology
- NWO Vidi 2019 - ZonMw
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
A sterile inflammatory response occurs in the absence of a pathogenic disease, in response to one’s own molecules. This occurs when our immune system fails to distinguish between our own molecules (self) and foreign molecules (non-self), leading to self-directed autoinflammatory and autoimmune disorders. The researchers will investigate the triggers underlying sterile inflammation.
Immune cells under control of sugars – Bart Everts - 2018
Dr. B. Everts
Department of Parasitology
- NWO Vidi 2018 - ZonMw
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Recent observations suggest that in immune cells, certain sugars can change protein activity by binding to them, which can subsequently lead to changes in immune cell function. This project will investigate how this exactly works and explore whether that knowledge can be utilized for therapeutic purposes.
A struggle for control – Gerbrand van der Heden-van Noort - 2018
Dr. G.J. van der Heden-van Noort
Department of Cell and Chemical Biology
- NWO Vidi 2018 - Science
- NWO contribution: EUR 800.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
The localization and activity of cellular proteins are regulated by dynamic post-translational modifications. It turns out these modifications are also modified themselves, leading to a novel hidden layer of control. The researchers aim to develop chemical tools to study these complex processes in detail.
Unmasking BRCA1’s Janus face in preventing tumour formation – Sylvie Noordermeer - 2018
Dr. S.M. Noordermeer
Department of Human Genetics
- NWO Vidi 2018 - Science
- NWO contribution: EUR 800,000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Faulty activities of the BRCA1-protein lead to tumour formation. BRCA1-activity depends on binding to many other proteins. However, it remains unclear how this is regulated. The researcher proposes to study why, when and where BRCA1 binds to those proteins and what effect disruption of the interactions has on tumour formation.
About NWO Vici
Vici is aimed at excellent senior researchers (within 15 years following their PhD defence, by submission deadline) who have successfully demonstrated their ability to develop their own innovative line of research. The maximum grant amount is 1.5 million euros.
NWO Vici
NOTCH3-brains@risk: the severe, the mild, and the unknown – Saskia Lesnik Oberstein - 2023
Dr S.A.J. Lesnik Oberstein
Department of Clinical Genetics
• NWO Vici 2023 – ZonMw
• NWO contribution: EUR 1.500,000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
One in 300 people worldwide are carriers of hereditary NOTCH3-dementia. NOTCH3-carriers develop protein clumps in the vessel walls of small brain arteries. This can cause vascular
Commensal Immune Modulators (CIM) boost PROtective immunity against respiratory Viral infections (CIMPROV) – Hermelijn Smits - 2022
Prof. dr. H.H. Smits
Department of Parasitology
• NWO Vici 2022 – ZonMw
• NWO contribution: EUR 1.500.000
• Start date: TBC - End date: TBC
• Host institution: LUMC
Short public summary:
Severe viral respiratory infections often occur in infants, older people or lung patients, leading to hospitalization or even death.
Stop-fix-go: dealing with roadblocks on the gene-track – Martijn Luijsterburg - 2021
Dr. S.M. Luijsterburg
Department of Human Genetics
- NWO Vici 2021 - Science
- NWO contribution: EUR 1.500.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
Protein machines that read our genes get stuck on damage in the DNA template. DNA damage must first be repaired before these protein machines can continue. How this works is currently unknown. The researchers will use genetic, cell biological and genome-wide methods to unravel how these processes work.
Damage during DNA replication: chromatin to the rescue! – Haico van Attikum - 2018
Prof. Dr. H. van Attikum
Department of Human Genetics
- NWO Vici 2018 - Science
- NWO contribution: EUR 1.500.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
An essential step of cell division is the replication of our DNA. Damage to our DNA, however, can hamper this process. The researchers will investigate how DNA replication is regulated in the presence of DNA damage and determine the role of chromatin, the packaging material of our DNA, therein.
Can cells change sex?– Susana Chuva de Sousa Lopes - 2018
Dr. S. Chuva de Sousa Lopes
Department of Anatomy and Embryology
- NWO Vici 2018 - ZonMw
- NWO contribution: EUR 1.500.000
- Start date: TBC - End date: TBC
- Host institution: LUMC
Short public summary:
During development, human cells make all organs and cell types, but can only generate one type of germline. Female cells can only make eggs and male cells only make sperm. Can we discover what regulates this process in humans and induce human stem cells to change sex in a dish?