The Biochemistry of Blood Coagulation

The Biochemistry of Blood Coagulation Research Group focuses on the molecular mechanisms that regulate the complex cascade of enzymatic reactions hallmarking blood coagulation. A better understanding of how disturbances in the function of components of the blood coagulation system lead to bleeding and thrombosis will provide the basis for the development of novel therapeutic approaches to treat these events. A large part of our research focuses on the engineering of innovative variants of blood

Experimental Approaches and Collaborations

The research activities focus on in vitro approaches to study coagulation pathways in detail and characterize recombinantly generated blood coagulation proteins. The methodologies used range from biophysical analyses to plasma-based assays. In addition, computational studies on protein structures and protein-ligand interactions provide the basis for the generation of recombinant protein variants with modified functions.

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Experimental Approaches and Collaborations

The research activities focus on in vitro approaches to study coagulation pathways in detail and characterize recombinantly generated blood coagulation proteins. The methodologies used range from biophysical analyses to plasma-based assays. In addition, computational studies on protein structures and protein-ligand interactions provide the basis for the generation of recombinant protein variants with modified functions.

We collaborate with national partners, including the Leiden Center of Protein Studies, the Expert Center for Treatment of Hemophilia and allied disorders LUMC-Hagaziekenhuis and the Vrije Universiteit Amsterdam, and with several international research groups.

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Themes for Innovation

Team Members

  • Dr. M.H.A. Bos, Assistant Professor
  • Prof. Dr. H.C.J. Eikenboom, Internist-vascular medicine / hematology
  • K.L. Cheung, MSc, Research Technician
  • V.J.F. Strijbis, MSc, PhD student
  • D. Veizaj, MSc, PhD student
  • Dr. J. Vatandoost, Postdoc

Key publications