Postdoctoral researcher
C. (Chloé) Najac, PhD
Scientific research
My research centers on developing and validating MR-based imaging and spectroscopy methods to assess metabolic and structural changes in the brain, providing insights into disease mechanisms and potential therapeutic targets. Until 2018, I conducted my research in a preclinical setup, transitioning to a clinical setup upon joining LUMC. I work with multiple MR systems, ranging from ultra-low magnetic fields (46mT) to ultra-high magnetic fields (7T).
On the ultra-low field MRI scanner, I am implementing and optimizing MRI protocols to create a robust clinical protocol for patient scanning. On the ultra-high field MRI scanner, I am involved in three clinical studies: one focusing on patients with classic-infantile Pompe disease, another on patients with Huntington’s disease (HD), and a third on patients with frontotemporal lobar dementia (FTLD). In these studies, we use MR spectroscopy methods developed in our group, evaluating their potential in non-invasively monitoring specific disease mechanisms, such as glycogen accumulation in Pompe disease or neuroinflammation in HD and FTLD.
On the ultra-low field MRI scanner, I am implementing and optimizing MRI protocols to create a robust clinical protocol for patient scanning. On the ultra-high field MRI scanner, I am involved in three clinical studies: one focusing on patients with classic-infantile Pompe disease, another on patients with Huntington’s disease (HD), and a third on patients with frontotemporal lobar dementia (FTLD). In these studies, we use MR spectroscopy methods developed in our group, evaluating their potential in non-invasively monitoring specific disease mechanisms, such as glycogen accumulation in Pompe disease or neuroinflammation in HD and FTLD.
