Head of Islet Research Lab
Assoc. Prof. F. (Françoise) Carlotti, PhD
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Introduction
I’m an Associate Professor at the Department of Internal Medicine.
I obtained a PhD in Molecular and Cellular Biology cum laude from the University of Nice-Sophia Antipolis (France) in 2004. During my training, I was granted a fellowship from the postgraduate training program Eurogendis (Eurolife network) and joined the Virus and Stem Cell Biology lab of Prof. Rob Hoeben at the LUMC. In 2006 I was appointed as a Staff Scientist. In 2010, I joined the Islet lab of Prof. Eelco de Koning as Assistant Professor, and then Associate Professor.
I obtained a PhD in Molecular and Cellular Biology cum laude from the University of Nice-Sophia Antipolis (France) in 2004. During my training, I was granted a fellowship from the postgraduate training program Eurogendis (Eurolife network) and joined the Virus and Stem Cell Biology lab of Prof. Rob Hoeben at the LUMC. In 2006 I was appointed as a Staff Scientist. In 2010, I joined the Islet lab of Prof. Eelco de Koning as Assistant Professor, and then Associate Professor.
Scientific research
I obtained research grants from JDRF, the Dutch Diabetes Research Foundation, the DON foundation, the European Foundation for the Study of Diabetes, and Health Holland. I’m PI in the Dutch consortium for regenerative medicine RegMedXB, and in the H2020 European consortia ISLET and ESPACE. I’m an Associate Investigator in the Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW.
I am in the management team of the LUMC Innovation Theme RegMedTO.
In the Islet lab, we do fundamental and pre-clinical research on type 1 and type 2 diabetes with a focus on primary human pancreatic cells and beta-cell replacement therapy building on an active clinical islet transplantation program.
Our two main research topics are:
i) Investigating mechanisms underlying beta-cell adaptation to (patho)physiological conditions, islet cell plasticity and alterations in beta-cell identity associated with a loss of function.
ii) Regenerative medicine for diabetes: Making new insulin-producing cells from human pluripotent stem cells using GMP-compliant processes for translation to the clinic.
I am in the management team of the LUMC Innovation Theme RegMedTO.
In the Islet lab, we do fundamental and pre-clinical research on type 1 and type 2 diabetes with a focus on primary human pancreatic cells and beta-cell replacement therapy building on an active clinical islet transplantation program.
Our two main research topics are:
i) Investigating mechanisms underlying beta-cell adaptation to (patho)physiological conditions, islet cell plasticity and alterations in beta-cell identity associated with a loss of function.
ii) Regenerative medicine for diabetes: Making new insulin-producing cells from human pluripotent stem cells using GMP-compliant processes for translation to the clinic.
