Professor of Kidney diseases
Prof. Dr. A.J. van Zonneveld
Area(s) of expertise:
Internal vascular medicine
Internal vascular medicine
Introduction
I am currently the chairman of the Einthoven Laboratory of Vascular and Regenerative Medicine. My academic research mainly focuses on the molecular mechanisms by which adverse metabolic and hemodynamic risk factors affect vascular homeostasis. I am also a member of the scientific advisory board of the Kidney Foundation and the Dutch Atherosclerosis Society.
I studied Biology at Leiden University in 1982, received my PhD from the University of Amsterdam in 1988 and did a postdoc at the Research Institute of Scripps Clinic, La Jolla. From 1998 to 2001, I served as Managing Director of Cardiovascular Research at Crucell Belgium NV. After returning to academia as head of the Department of Vascular Medicine at UMC in 2003, I moved to my current position in the Department of Internal Medicine (Nephrology) at LUMC in 2004. My current research mainly focuses on posttranscriptional mechanisms in microvascular loss and repair in patients with renal disease and renal transplant patients.
I studied Biology at Leiden University in 1982, received my PhD from the University of Amsterdam in 1988 and did a postdoc at the Research Institute of Scripps Clinic, La Jolla. From 1998 to 2001, I served as Managing Director of Cardiovascular Research at Crucell Belgium NV. After returning to academia as head of the Department of Vascular Medicine at UMC in 2003, I moved to my current position in the Department of Internal Medicine (Nephrology) at LUMC in 2004. My current research mainly focuses on posttranscriptional mechanisms in microvascular loss and repair in patients with renal disease and renal transplant patients.
Scientific research
His current research mainly focuses on posttranscriptional mechanisms in microvascular loss and repair. Progressive loss of microvascular integrity and tissue perfusion is a hallmark of many of the cardiovascular complications of (diabetes) patients with chronic kidney disease. Also, in kidney transplantation, ischemia reperfusion injury and rejection result in the loss of microvasculature. While vascular surgeons and intervention cardiologist have highly sophisticated tools to repair our larger conduit vessels, such as occluded coronary arteries by performing angioplasty or by placing stents, therapeutic strategies to protect or restore the microvasculature remains an unmet clinical need and are the main goal of the research topics in the Vascular Nephrology Group.
