N. (Nienke) van Rein, PharmD PhD

Nienke van Rein studied pharmacy in Groningen and obtained her PhD at the department of Thrombosis and Haemostasis in the LUMC. In the LUMC, she continued as a resident hospital pharmacy. She now works as a hospital pharmacist at the department of Clinical Pharmacy and Toxicology and is responsible for the logistics of medications for admitted patients and for trials with medication in the LUMC. Besides that, she performs pharmacoepidemiological research on the department of Clinical Epidemiology with the ultimate goal to optimize efficacy and safety of medication, with a special interest in antithrombotic medication. She gives education on epidemiology, study design, (anti)coagulation and trials to students from studies such as pharmacy, medicine, biopharmaceutical sciences and biomedical sciences. Furthermore, she takes part in multiple guideline committees on antithrombotic treatment.

The main field of Nienke her research is the balance of efficacy and safety of cardiovascular medication. Her pharmacoepidemiological research has multiple pillars to achieve this aim, which are:
- large populations to balance efficacy and safety of anticoagulation treatment by means of nationwide databases in the Netherland and Denmark (big data).
- markers in plasma and DNA in large cohorts of patients on anticoagulant treatment (proteomics and pharmacogenetics).
- high risk groups and improve efficacy and safety such as Left Ventricular Assist Device patients, patients extreme body weights, with triple therapy, interacting medication or around surgery.
- the duration of anticoagulant treatment on an individual basis in patients receiving anticoagulants by means of large prospective (randomized) studies (personalized medicine).
By using large datasets, new technologies and performing prospective research, she aims to further improve safety of patients on anticoagulants.