PhD Candidate Mechanisms of DNA Break Repair
You have 16 more days to apply
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About your role
As a PhD candidate, you will join the Genome Instability and Genome Engineering research group, led by Professor Tijsterman. Working closely with Dr. Marco Barazas, you will explore the molecular mechanisms of newly identified proteins involved in DNA break repair. This project builds upon our recently developed Mutational Signature Catalogue (MUSIC), which maps repair outcome profiles for every gene knockout in the genome. You will apply a range of cellular assays, genomic tools, and advanced sequencing techniques to study the polymerase-theta-mediated end-joining pathway. Additionally, you will work to identify new potential cancer drug targets and clarify their mechanisms of action. Your top five tasks are:
- Design and conduct experiments to analyze the role of specific proteins in DNA break repair.
- Apply advanced sequencing techniques and genomic tools to map mutation patterns.
- Develop and optimize cellular assays to investigate DNA repair mechanisms.
- Collaborate with colleagues within and beyond the research group and present findings at (inter)national conferences.
- Publish research findings in scientific journals and work towards completing your PhD thesis.
This PhD project offers a stimulating and innovative research environment where you will contribute to both fundamental and applied cancer research. You will have the opportunity to work with cutting-edge technologies and collaborate with leading experts in genome instability and DNA repair.
About your workplace
The department of Human Genetics is a broadly oriented research department, led by Professor Silvère van der Maarel, with a focus on the (epi)genomic contribution to monogenic, multifactorial, and acquired diseases, and the translation into clinical relevance. The department consists of 22 research units, embedded in four overarching research lines. Currently, the department has about 220 (inter)national employees, ranging from professors, students, and research technicians to researchers and PhD students.
You will work in the group of Prof. Marcel Tijsterman. The research group focuses on understanding the mechanisms that prevent or cause genome instability and mutagenesis. In addition, we exploit newly obtained knowledge to improve genome engineering approaches. A variety of model systems are used to study how cells and organisms repair DNA breaks.
About you
You are an enthusiastic and ambitious researcher with a strong drive to unravel complex mechanistic research questions. You thrive in a dynamic team environment and combine a critical and independent mindset with an organized and structured approach. Additionally, you are flexible and possess excellent communication skills in both spoken and written English. Furthermore, you have:
- A master’s degree in biomedical sciences or a related field.
- Practical experience with common molecular techniques, such as molecular cloning and mammalian cell culture.
- Preferably, experience with CRISPR-Cas9 gene editing, next-generation sequencing, and/or bioinformatics analyses.
- The ability to work both independently and collaboratively within a research team.
Our offer
Driven by health; that's our mission. This applies not only to our patients but also to our employees. We strive to provide a safe, inclusive and equitable work environment, with a focus on talent development and connected leadership. In order to be able to continue to learn and develop, we offer internal and external training. You are also entitled to an end-of-year bonus (8,3%), holiday allowance, sports budget, bicycle scheme, home office allowance and an excellent commuting allowance. Furthermore, as an employee of LUMC, you are also affiliated with the ABP pension fund. This means that 70% of your pension premium is paid by LUMC, leaving you with a higher net salary. Nice, right?
What do we represent?
As an academic medical center, LUMC strives to have a workforce that is a good reflection of society. We are committed to the highest quality in health care, education and (international) research, in which diverse perspectives are essential. Sustainability is also a high priority for us: we are committed to a healthy future, not only for people, but also for the planet. In line with these values, we aim to be a creative and inspiring place to work, where everyone feels at home, safe and valued. It's all about who you are and what you bring to contribute, regardless of your background. Together, we work toward a sustainable and inclusive future, both for the people around us and for the world we live in. Together, we are LUMC.
More information
- As a PhD candidate, your salary will range from €3,017 to €3,824 gross per month (scale Pro, CAO UMC). These figures are based on a full-time position.
- Please include the names and contact details of two references with your application.
- The duration of employment is for the length of the PhD program, which is four years.
- Applications from employment/recruitment agencies will not be considered.
- You can also require more information from Marco Barazas, m.barazas@lumc.nl