B. (Balázs) Örzsik, PhD

In my role at LUMC, I specialize in using high-resolution dynamic CSF imaging, a pioneering technique developed by the C.J. Gorter group, to unveil the critical role of sleep in brain clearance processes. My academic journey began at the University of Bristol, where I immersed myself in the fundamentals of neuroscience for my BSc. Later, at the University of Sussex, I pursued a Ph.D., employing multimodal MRI to delve into brain clearance during sleep. After my Ph.D., I worked as a post-doc at the University of Sussex, investigating brain metabolism in psychiatric conditions using MRI. Beyond academia, I find solace in golf, as it mirrors the perseverance and dedication demanded in science. The great Arnold Palmer's insight, "It's a strange thing, the more I practice the luckier I get," resonates deeply in both science and golf, emphasizing the direct correlation between effort and success in each pursuit.

My research endeavors center around the fundamental importance of brain clearance mechanisms and their intricate relationship with sleep. Through high-resolution dynamic CSF imaging, I delve into the pivotal role of sleep in facilitating brain clearance processes. This exploration extends beyond mere curiosity, as disruptions in sleep patterns are increasingly recognized as potential contributors to neurodegenerative conditions. While my primary focus lies in brain clearance and sleep, I am concurrently engaged in a side project that investigates the role of arachnoid granulations, historically understudied structures with potential implications for brain health. By meticulously segmenting these structures in CAA patients and controls, I aim to elucidate their function and establish potential links between brain clearance and neuroinflammation.