Cancer Immunogenomics

Our group performs basic and translational research in the fields of cancer genetics, immunology and immunotherapy. In specific, we are interested in targeting cancer-specific (neo) antigens and in exploiting unconventional immune cell subsets for the development of novel immunotherapeutic approaches.

Applying multidimensional approaches to decipher biology

The Cancer Immunogenomics group is highly proficient in employing state-of-the-art technologies including bulk and single cell sequencing, spatial transcriptomics, and single cell and imaging mass cytometry. These approaches provide unprecedented insights into the complex and multicellular nature of cancer microenvironments and the biological processes governing cancer immunity.

…

Applying multidimensional approaches to decipher biology

The Cancer Immunogenomics group is highly proficient in employing state-of-the-art technologies including bulk and single cell sequencing, spatial transcriptomics, and single cell and imaging mass cytometry. These approaches provide unprecedented insights into the complex and multicellular nature of cancer microenvironments and the biological processes governing cancer immunity.

Scientific questions with clinical relevance

We are particularly interested in developing novel immunotherapeutic approaches cancers where current immunotherapeutic approaches are not effective like colorectal cancers with low mutation burden and pancreatic cancers. Recently, we teamed up with the Bone and Soft Tissue research group (PI: Prof.dr. Judith Bovée) to investigate the potential of immunotherapy in bone and soft tissue cancers.

Our team members

  • Noel de Miranda, PI.
  • Dina Ruano, Senior Researcher.
  • Manon van der Ploeg, Technician.
  • Ruud van der Breggen Technician.
  • Jessica Roelands, Postdoc.
  • Joana Brás Gomes Nunes, Postdoc.
  • Marieke Ijsselsteijn, PhD student.
  • Ricki Krog, PhD student.
  • Zheng Li, PhD student.

Team.jpg